Endocrine Abstracts

Objectives: There is strong epidemiological evidence that insulin resistance confers a significantly increased risk of cardiovascular disease independent of other cardiovascular risk factors. The aim of the study is to compare the insulin resistance levels in metabolic syndrome of polycystic ovarian syndrome (PCOS) with that of type 2 diabetes (T2DM).Methods: The biological variation of IR was assessed by measuring IR at four day intervals on 10 consecut...

OBJECTIVE: To evaluate and compare the effect of treatment with orlistat versus metformin on the hormonal and biochemical features of patients with polycystic ovarian syndrome (PCOS)METHODS: 21 Caucasian women with PCOS (mean plus/minus SEM, age 27 plus/minus 0.9 years, and body mass index 36.7 plus/minus 3.3) participated in this prospective, randomised, open labelled, study. All subjects had an eight week run in period of dietary modification and then ...

Objectives: We have recently demonstrated a wide variation in insulin resistance (IR) occurs in polycystic ovarian syndrome and type 2 diabetes. Changes in insulin metabolism and increased insulin resistance (IR) after the menopause have previously been reported. It is unknown if the biological variation of IR is affected by the menopause and is evaluated here.Methods: The biological variation of IR was assessed by measuring IR at four day intervals on 10 consecutive occas...

Objective: Bioavailable testosterone (BioT) is measured directly by bioassay or estimated by calculating the free androgen index (FAI) and reflects hyperandrogenaemia more accurately than measurement of total testosterone in plasma. A comparison of the biological variation of FAI and measured BioT was undertaken to determine the relative suitability of these estimates in PCOS.Method: The biological variation of BioT and FAI was assessed in 12 PCOS patients (median age 28yr...

Introduction: Reduced sex hormone binding globulin (SHBG) is seen in patients with polycystic ovarian syndrome (PCOS) and is considered a surrogate marker of hyperinsulinaemia in these patients. Little data currently exists on the biological variability of SHBG for an individual with PCOS and this information is crucial to establish its clinical utility. Method: 12 PCOS patients (median age 28 yrs, range 18-31) and 11 weight matched, control women having regular menses and wit...

AIMS: Postmenopausal oestrogen replacement therapy (ERT) has been shown to lower serum insulin-like growth factor 1 (IGF-1) levels, requiring the use of higher doses of growth hormone (GH) replacement. Soy derived phytoestrogens (PE) are in widespread usage as a natural alternative to ERT. No data exists on the effects of PE on serum IGF-1 levels. The aim of this pilot study was to determine the effects of Phytoestrogen dietary supplementation on the serum IGF-1 level in postm...